Development And In-Vitro Evaluation of Diclofenac Sodium Loaded Microsphere For Sustained Delivery

Diclofenac sodium is a Non-Steroidal Anti-inflammatory Drug, active against relief from pain and inflammation. The main objective of this research work was to prepare Ethyl Cellulose microsphere loaded with Diclofenac and invitro drug release study. In the present study, emulsion Solvent Evaporation Method is used for preparing microsphere. The polymer (EC) and drug (Diclofenac Sodium) was dissolved in Acetone. Surfactant was dissolved in acetone. Surfactant was added to this solution and stirred it for 30 min. The oil and 1 drop of span-80, span-20, tween80, tween20(as emulsifier) were mixed together and allowed to stirred it for 2 hours at 800-1000 rpm. The aqueous phase was added to oil phase to form primary emulsion. This emulsion was stirred for 3 hours at 800-1000 rpm. Microsphere were filtered and dried in desiccator overnight. Microsphere were and smooth surface. Infra-red spectra showed identical peaks of drug and polymer drug entrapment efficiency was 92% determined by UVSpectrophotometer at 273 nm. Invitro drug release studies were performed using USP-II Dissolution Apparatus. The formulation EC showed 88.5% drug was released in 10 hours. It is conclude that EC microsphere of Diclofenac sodium can be prepared by emulsification Solvent Evaporation Method, and also aimed to reduce gastric irritation by preparing microsphere of Diclofenac Sodium. The formulation showed 92.25 drug was released in 24 hours.